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Multifunctional, JNK-inhibiting nanotherapeutics for augmented elastic matrix regenerative repair in aortic aneurysms

Growth of abdominal aortic aneurysms (AAA), localized aortal wall expansions, is driven by the disruption and subsequent loss of aortal wall elastic fibers by matrix metalloproteases (MMPs). Since elastic fibers do not naturally regenerate or repair, arresting/reversing AAA growth has not been possi...

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Podrobná bibliografie
Vydáno v:Drug Deliv Transl Res
Hlavní autoři: Camardo, Andrew, Seshadri, Dhruv, Broekelmann, Tom, Mecham, Robert, Ramamurthi, Anand
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837892/
https://ncbi.nlm.nih.gov/pubmed/28875468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13346-017-0419-y
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