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Fibrinolytic PLGA nanoparticles for slow clot lysis within abdominal aortic aneurysms attenuate proteolytic loss of vascular elastic matrix

Abdominal aortic aneurysms (AAAs) involve chronic overexpression of proteases in the aortic wall that result in disruption of elastic fibers and consequent loss of vessel elasticity. Nearly 75% of AAAs contain flow-obstructing, fibrin-rich intraluminal thrombi (ILT), which act as a) a bioinert shiel...

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Detalhes bibliográficos
Publicado no:Mater Sci Eng C Mater Biol Appl
Main Authors: Sivaraman, Balakrishnan, Sylvester, Andrew, Ramamurthi, Anand
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784758/
https://ncbi.nlm.nih.gov/pubmed/26652359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.msec.2015.09.056
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