From the Cover: ROS-Induced Store-Operated Ca(2+) Entry Coupled to PARP-1 Hyperactivation Is Independent of PARG Activity in Necrotic Cell Death

2,3,5-tris(Glutathion-S-yl)hydroquinone, a potent nephrotoxic and nephrocarcinogenic metabolite of benzene and hydroquinone, generates reactive oxygen species (ROS) causing DNA strand breaks and the subsequent activation of DNA repair enzymes, including poly(ADP-ribose) polymerase (PARP)-1. Under ro...

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Vydáno v:Toxicol Sci
Hlavní autoři: Munoz, Frances M., Zhang, Fengjiao, Islas-Robles, Argel, Lau, Serrine S., Monks, Terrence J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Calcium and Parp-1 Signaling in Proximal Tubule Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837598/
https://ncbi.nlm.nih.gov/pubmed/28525621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx106
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