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Structure-Based Design and Discovery of New M(2) Receptor Agonists

Muscarinic receptor agonists are characterized by apparently strict restraints on their tertiary or quaternary amine and their distance to an ester or related center. On the basis of the active state crystal structure of the muscarinic M(2) receptor in complex with iperoxo, we explored potential ago...

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Bibliographische Detailangaben
Veröffentlicht in:J Med Chem
Hauptverfasser: Fish, Inbar, Stößel, Anne, Eitel, Katrin, Valant, Celine, Albold, Sabine, Huebner, Harald, Möller, Dorothee, Clark, Mary J., Sunahara, Roger K., Christopoulos, Arthur, Shoichet, Brian K., Gmeiner, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836741/
https://ncbi.nlm.nih.gov/pubmed/29094937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01113
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