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Structure-Based Design and Discovery of New M(2) Receptor Agonists
Muscarinic receptor agonists are characterized by apparently strict restraints on their tertiary or quaternary amine and their distance to an ester or related center. On the basis of the active state crystal structure of the muscarinic M(2) receptor in complex with iperoxo, we explored potential ago...
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| Pubblicato in: | J Med Chem |
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| Autori principali: | , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5836741/ https://ncbi.nlm.nih.gov/pubmed/29094937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01113 |
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