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A UNIFIED FRAMEWORK FOR VARIANCE COMPONENT ESTIMATION WITH SUMMARY STATISTICS IN GENOME-WIDE ASSOCIATION STUDIES()

Linear mixed models (LMMs) are among the most commonly used tools for genetic association studies. However, the standard method for estimating variance components in LMMs—the restricted maximum likelihood estimation method (REML)—suffers from several important drawbacks: REML requires individual-lev...

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Publicat a:Ann Appl Stat
Autor principal: Zhou, Xiang
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836736/
https://ncbi.nlm.nih.gov/pubmed/29515717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1214/17-AOAS1052
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