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A UNIFIED FRAMEWORK FOR VARIANCE COMPONENT ESTIMATION WITH SUMMARY STATISTICS IN GENOME-WIDE ASSOCIATION STUDIES()
Linear mixed models (LMMs) are among the most commonly used tools for genetic association studies. However, the standard method for estimating variance components in LMMs—the restricted maximum likelihood estimation method (REML)—suffers from several important drawbacks: REML requires individual-lev...
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| Publicado no: | Ann Appl Stat |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5836736/ https://ncbi.nlm.nih.gov/pubmed/29515717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1214/17-AOAS1052 |
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