Estimating genetic nurture with summary statistics of multigenerational genome-wide association studies

Marginal effect estimates in genome-wide association studies (GWAS) are mixtures of direct and indirect genetic effects. Existing methods to dissect these effects require family-based, individual-level genetic, and phenotypic data with large samples, which is difficult to obtain in practice. Here, w...

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Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Wu, Yuchang, Zhong, Xiaoyuan, Lin, Yunong, Zhao, Zijie, Chen, Jiawen, Zheng, Boyan, Li, James J., Fletcher, Jason M., Lu, Qiongshi
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2021
Предметы:
Social Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237646/
https://ncbi.nlm.nih.gov/pubmed/34131076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023184118
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