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LY294002 inhibits the Warburg effect in gastric cancer cells by downregulating pyruvate kinase M2
The ‘Warburg effect’ is considered a vital hallmark of cancer cells, characterized by an altered metabolism, in which cells rely on aerobic glycolysis. As a key enzyme of aerobic glycolysis, pyruvate kinase M2 (PKM2) serves a crucial role in tumorigenesis. Accumulating studies have indicated that PK...
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| Publicado no: | Oncol Lett |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
D.A. Spandidos
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5835956/ https://ncbi.nlm.nih.gov/pubmed/29541204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2018.7843 |
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