LY294002 inhibits the Warburg effect in gastric cancer cells by downregulating pyruvate kinase M2

The ‘Warburg effect’ is considered a vital hallmark of cancer cells, characterized by an altered metabolism, in which cells rely on aerobic glycolysis. As a key enzyme of aerobic glycolysis, pyruvate kinase M2 (PKM2) serves a crucial role in tumorigenesis. Accumulating studies have indicated that PK...

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Bibliografiske detaljer
Udgivet i:Oncol Lett
Main Authors: Lu, Jian, Chen, Min, Gao, Sumeng, Yuan, Jigang, Zhu, Zhu, Zou, Xiaoping
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2018
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835956/
https://ncbi.nlm.nih.gov/pubmed/29541204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2018.7843
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