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New roles for pyruvate kinase M2: working out the Warburg effect

The origins and role of the Warburg effect have remained uncertain for many years. Two recent studies demonstrate that an embryonic- and cancer-cell-specific isoform of the enzyme pyruvate kinase M2 (PKM2) is regulated by binding to phospho-tyrosine motifs and promotes increased cell growth and tumo...

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Dettagli Bibliografici
Autori principali: Ferguson, Emily C., Rathmell, Jeffrey C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590867/
https://ncbi.nlm.nih.gov/pubmed/18603432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2008.05.006
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