Conformational stability of the epidermal growth factor (EGF) receptor as influenced by glycosylation, dimerization and EGF hormone binding

The epidermal growth factor receptor (EGFR) is an important transmembrane glycoprotein kinase involved the initiation or perpetuation of signal transduction cascades within cells. These processes occur after EGFR binds to a ligand [epidermal growth factor (EGF)], thus inducing its dimerization and t...

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Vydáno v:Proteins
Hlavní autoři: Taylor, Eric S., Pol-Fachin, Laercio, Lins, Roberto D., Lower, Steven K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835389/
https://ncbi.nlm.nih.gov/pubmed/28019699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25220
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