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The impact of glycosylation on monoclonal antibody conformation and stability

Antibody glycosylation is a common post-translational modification and has a critical role in antibody effector function. The use of glycoengineering to produce antibodies with specific glycoforms may be required to achieve the desired therapeutic efficacy. However, the modified molecule could have...

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Main Authors: Zheng, Kai, Bantog, Christopher, Bayer, Robert
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2011
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242843/
https://ncbi.nlm.nih.gov/pubmed/22123061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.6.17922
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