Conformational stability and aggregation of therapeutic monoclonal antibodies studied with ANS and thioflavin T binding

Characterization of aggregation profiles of monoclonal antibodies (mAb) is gaining importance because an increasing number of mAb-based therapeutics are entering clinical studies and gaining marketing approval. To develop a successful formulation, it is imperative to identify the critical biochemica...

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Bibliographic Details
Main Authors: Kayser, Veysel, Chennamsetty, Naresh, Voynov, Vladimir, Helk, Bernhard, Trout, Bernhardt L
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2011
Subjects:
Brief Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218538/
https://ncbi.nlm.nih.gov/pubmed/21540645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.4.15677
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