Dynamic Fluctuations of Protein-Carbohydrate Interactions Promote Protein Aggregation

Protein-carbohydrate interactions are important for glycoprotein structure and function. Antibodies of the IgG class, with increasing significance as therapeutics, are glycosylated at a conserved site in the constant Fc region. We hypothesized that disruption of protein-carbohydrate interactions in...

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Detalhes bibliográficos
Main Authors: Voynov, Vladimir, Chennamsetty, Naresh, Kayser, Veysel, Helk, Bernhard, Forrer, Kurt, Zhang, Heidi, Fritsch, Cornelius, Heine, Holger, Trout, Bernhardt L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791859/
https://ncbi.nlm.nih.gov/pubmed/20037630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008425
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