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Conformational stability and aggregation of therapeutic monoclonal antibodies studied with ANS and thioflavin T binding
Characterization of aggregation profiles of monoclonal antibodies (mAb) is gaining importance because an increasing number of mAb-based therapeutics are entering clinical studies and gaining marketing approval. To develop a successful formulation, it is imperative to identify the critical biochemica...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Landes Bioscience
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3218538/ https://ncbi.nlm.nih.gov/pubmed/21540645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.4.15677 |
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