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Conformational stability of the epidermal growth factor (EGF) receptor as influenced by glycosylation, dimerization and EGF hormone binding

The epidermal growth factor receptor (EGFR) is an important transmembrane glycoprotein kinase involved the initiation or perpetuation of signal transduction cascades within cells. These processes occur after EGFR binds to a ligand [epidermal growth factor (EGF)], thus inducing its dimerization and t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Proteins
Hauptverfasser: Taylor, Eric S., Pol-Fachin, Laercio, Lins, Roberto D., Lower, Steven K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835389/
https://ncbi.nlm.nih.gov/pubmed/28019699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25220
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