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Synaptotoxic Signaling by Amyloid Beta Oligomers in Alzheimer's Disease Through Prion Protein and mGluR5

Alzheimer's disease (AD) represents an impending global health crisis, yet the complexity of AD pathophysiology has so far precluded the development of any interventions to successfully slow or halt AD progression. It is clear that accumulation of Amyloid-beta (Aβ) peptide triggers progressive...

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Publicado en:Adv Pharmacol
Autores principales: Brody, A.H., Strittmatter, Stephen M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835229/
https://ncbi.nlm.nih.gov/pubmed/29413525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.apha.2017.09.007
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