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Synaptotoxic Signaling by Amyloid Beta Oligomers in Alzheimer's Disease Through Prion Protein and mGluR5

Alzheimer's disease (AD) represents an impending global health crisis, yet the complexity of AD pathophysiology has so far precluded the development of any interventions to successfully slow or halt AD progression. It is clear that accumulation of Amyloid-beta (Aβ) peptide triggers progressive...

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Detalhes bibliográficos
Publicado no:Adv Pharmacol
Main Authors: Brody, A.H., Strittmatter, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835229/
https://ncbi.nlm.nih.gov/pubmed/29413525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.apha.2017.09.007
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