Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex

The prion protein (PrP(C)) has been suggested to operate as a scaffold/receptor protein in neurons, participating in both physiological and pathological associated events. PrP(C), laminin, and metabotropic glutamate receptor 5 (mGluR5) form a protein complex on the plasma membrane that can trigger s...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Beraldo, Flavio H., Ostapchenko, Valeriy G., Caetano, Fabiana A., Guimaraes, Andre L. S., Ferretti, Giulia D. S., Daude, Nathalie, Bertram, Lisa, Nogueira, Katiane O. P. C., Silva, Jerson L., Westaway, David, Cashman, Neil R., Martins, Vilma R., Prado, Vania F., Prado, Marco A. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063978/
https://ncbi.nlm.nih.gov/pubmed/27563063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738286
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