Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex

The prion protein (PrP(C)) has been suggested to operate as a scaffold/receptor protein in neurons, participating in both physiological and pathological associated events. PrP(C), laminin, and metabotropic glutamate receptor 5 (mGluR5) form a protein complex on the plasma membrane that can trigger s...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Beraldo, Flavio H., Ostapchenko, Valeriy G., Caetano, Fabiana A., Guimaraes, Andre L. S., Ferretti, Giulia D. S., Daude, Nathalie, Bertram, Lisa, Nogueira, Katiane O. P. C., Silva, Jerson L., Westaway, David, Cashman, Neil R., Martins, Vilma R., Prado, Vania F., Prado, Marco A. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063978/
https://ncbi.nlm.nih.gov/pubmed/27563063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738286
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