The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to β-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment

In Alzheimer's disease, accumulation of soluble oligomers of β-amyloid peptide is known to be highly toxic, causing disturbances in synaptic activity and neuronal death. Multiple studies relate these effects to increased oxidative stress and aberrant activity of calcium-permeable cation channel...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Ostapchenko, Valeriy G., Chen, Megan, Guzman, Monica S., Xie, Yu-Feng, Lavine, Natalie, Fan, Jue, Beraldo, Flavio H., Martyn, Amanda C., Belrose, Jillian C., Mori, Yasuo, MacDonald, John F., Prado, Vania F., Prado, Marco A.M., Jackson, Michael F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2015
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605355/
https://ncbi.nlm.nih.gov/pubmed/26558786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4081-14.2015
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