Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis

RIPK1 is a critical mediator of cell death and inflammation downstream of TNFR1 upon stimulation by TNFα, a potent proinflammatory cytokine involved in a multitude of human inflammatory and degenerative diseases. RIPK1 contains an N-terminal kinase domain, an intermediate domain, and a C-terminal de...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Meng, Huyan, Liu, Zhen, Li, Xingyan, Wang, Huibing, Jin, Taijie, Wu, Guowei, Shan, Bing, Christofferson, Dana E., Qi, Chunting, Yu, Qiang, Li, Ying, Yuan, Junying
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834731/
https://ncbi.nlm.nih.gov/pubmed/29440439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722013115
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