Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

Stimulation of TNFR1 by TNFα can promote three distinct alternative mechanisms of cell death: necroptosis, RIPK1-independent and -dependent apoptosis. How cells decide which way to die is unclear. Here, we report that TNFα-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a k...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Geng, Jiefei, Ito, Yasushi, Shi, Linyu, Amin, Palak, Chu, Jiachen, Ouchida, Amanda Tomie, Mookhtiar, Adnan Kasim, Zhao, Heng, Xu, Daichao, Shan, Bing, Najafov, Ayaz, Gao, Guangping, Akira, Shizuo, Yuan, Junying
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572456/
https://ncbi.nlm.nih.gov/pubmed/28842570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00406-w
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