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RIPK1 Mediates Axonal Degeneration By Promoting Inflammation and Necroptosis in ALS
Mutations in Optineurin (Optn) gene have been implicated in both familial and sporadic amyotrophic lateral sclerosis (ALS). However, the role of this protein in the central nervous system (CNS) and how it may contribute to ALS pathology is unclear. Here, we found that optineurin actively suppressed...
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| Izdano u: | Science |
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| Glavni autori: | , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5444917/ https://ncbi.nlm.nih.gov/pubmed/27493188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf6803 |
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