RIPK1 Mediates Axonal Degeneration By Promoting Inflammation and Necroptosis in ALS

Mutations in Optineurin (Optn) gene have been implicated in both familial and sporadic amyotrophic lateral sclerosis (ALS). However, the role of this protein in the central nervous system (CNS) and how it may contribute to ALS pathology is unclear. Here, we found that optineurin actively suppressed...

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Publicado no:Science
Main Authors: Ito, Yasushi, Ofengeim, Dimitry, Najafov, Ayaz, Das, Sudeshna, Saberi, Shahram, Li, Ying, Hitomi, Junichi, Zhu, Hong, Chen, Hongbo, Mayo, Lior, Geng, Jiefei, Amin, Palak, DeWitt, Judy Park, Mookhtiar, Adnan Kasim, Florez, Marcus, Ouchida, Amanda Tomie, Fan, Jian-bing, Pasparakis, Manolis, Kelliher, Michelle A., Ravits, John, Yuan, Junying
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444917/
https://ncbi.nlm.nih.gov/pubmed/27493188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf6803
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