RIPK1 Mediates Axonal Degeneration By Promoting Inflammation and Necroptosis in ALS

Mutations in Optineurin (Optn) gene have been implicated in both familial and sporadic amyotrophic lateral sclerosis (ALS). However, the role of this protein in the central nervous system (CNS) and how it may contribute to ALS pathology is unclear. Here, we found that optineurin actively suppressed...

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Bibliografski detalji
Izdano u:Science
Glavni autori: Ito, Yasushi, Ofengeim, Dimitry, Najafov, Ayaz, Das, Sudeshna, Saberi, Shahram, Li, Ying, Hitomi, Junichi, Zhu, Hong, Chen, Hongbo, Mayo, Lior, Geng, Jiefei, Amin, Palak, DeWitt, Judy Park, Mookhtiar, Adnan Kasim, Florez, Marcus, Ouchida, Amanda Tomie, Fan, Jian-bing, Pasparakis, Manolis, Kelliher, Michelle A., Ravits, John, Yuan, Junying
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444917/
https://ncbi.nlm.nih.gov/pubmed/27493188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf6803
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