ATP-competitive Plk1 inhibitors induce caspase 3-mediated Plk1 cleavage and activation in hematopoietic cell lines

Polo-like kinases (Plks) define a highly conserved family of Ser/Thr kinases with crucial roles in the regulation of cell division. Here we show that Plk1 is cleaved by caspase 3, but not by other caspases in different hematopoietic cell lines treated with competitive inhibitors of the ATP-binding p...

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Publicado en:Oncotarget
Autores principales: Dufies, Maeva, Ambrosetti, Damien, Boulakirba, Sonia, Calleja, Anne, Savy, Coline, Furstoss, Nathan, Zerhouni, Marwa, Parola, Julien, Aira-Diaz, Lazaro, Marchetti, Sandrine, Orange, Francois, Lacas-Gervais, Sandra, Luciano, Frederic, Jacquel, Arnaud, Robert, Guillaume, Pagès, Gilles, Auberger, Patrick
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834281/
https://ncbi.nlm.nih.gov/pubmed/29541386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23650
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