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Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux

Metastatic renal cell carcinomas (mRCC) are highly vascularized tumors that are a paradigm for the treatment with antiangiogenesis drugs targeting the vascular endothelial growth factor (VEGF) pathway. The available drugs increase the time to progression but are not curative and the patients eventua...

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Detaylı Bibliyografya
Yayımlandı:Autophagy
Asıl Yazarlar: Giuliano, Sandy, Cormerais, Yann, Dufies, Maeva, Grépin, Renaud, Colosetti, Pascal, Belaid, Amine, Parola, Julien, Martin, Anthony, Lacas-Gervais, Sandra, Mazure, Nathalie M, Benhida, Rachid, Auberger, Patrick, Mograbi, Baharia, Pagès, Gilles
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824581/
https://ncbi.nlm.nih.gov/pubmed/26312386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1085742
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