Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux

Metastatic renal cell carcinomas (mRCC) are highly vascularized tumors that are a paradigm for the treatment with antiangiogenesis drugs targeting the vascular endothelial growth factor (VEGF) pathway. The available drugs increase the time to progression but are not curative and the patients eventua...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Giuliano, Sandy, Cormerais, Yann, Dufies, Maeva, Grépin, Renaud, Colosetti, Pascal, Belaid, Amine, Parola, Julien, Martin, Anthony, Lacas-Gervais, Sandra, Mazure, Nathalie M, Benhida, Rachid, Auberger, Patrick, Mograbi, Baharia, Pagès, Gilles
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Translational Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824581/
https://ncbi.nlm.nih.gov/pubmed/26312386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1085742
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