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Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux

Metastatic renal cell carcinomas (mRCC) are highly vascularized tumors that are a paradigm for the treatment with antiangiogenesis drugs targeting the vascular endothelial growth factor (VEGF) pathway. The available drugs increase the time to progression but are not curative and the patients eventua...

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Bibliografiske detaljer
Udgivet i:Autophagy
Main Authors: Giuliano, Sandy, Cormerais, Yann, Dufies, Maeva, Grépin, Renaud, Colosetti, Pascal, Belaid, Amine, Parola, Julien, Martin, Anthony, Lacas-Gervais, Sandra, Mazure, Nathalie M, Benhida, Rachid, Auberger, Patrick, Mograbi, Baharia, Pagès, Gilles
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Translational Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824581/
https://ncbi.nlm.nih.gov/pubmed/26312386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1085742
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