ATP-competitive Plk1 inhibitors induce caspase 3-mediated Plk1 cleavage and activation in hematopoietic cell lines

Polo-like kinases (Plks) define a highly conserved family of Ser/Thr kinases with crucial roles in the regulation of cell division. Here we show that Plk1 is cleaved by caspase 3, but not by other caspases in different hematopoietic cell lines treated with competitive inhibitors of the ATP-binding p...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Dufies, Maeva, Ambrosetti, Damien, Boulakirba, Sonia, Calleja, Anne, Savy, Coline, Furstoss, Nathan, Zerhouni, Marwa, Parola, Julien, Aira-Diaz, Lazaro, Marchetti, Sandrine, Orange, Francois, Lacas-Gervais, Sandra, Luciano, Frederic, Jacquel, Arnaud, Robert, Guillaume, Pagès, Gilles, Auberger, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834281/
https://ncbi.nlm.nih.gov/pubmed/29541386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23650
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