ATP-competitive Plk1 inhibitors induce caspase 3-mediated Plk1 cleavage and activation in hematopoietic cell lines

Polo-like kinases (Plks) define a highly conserved family of Ser/Thr kinases with crucial roles in the regulation of cell division. Here we show that Plk1 is cleaved by caspase 3, but not by other caspases in different hematopoietic cell lines treated with competitive inhibitors of the ATP-binding p...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Dufies, Maeva, Ambrosetti, Damien, Boulakirba, Sonia, Calleja, Anne, Savy, Coline, Furstoss, Nathan, Zerhouni, Marwa, Parola, Julien, Aira-Diaz, Lazaro, Marchetti, Sandrine, Orange, Francois, Lacas-Gervais, Sandra, Luciano, Frederic, Jacquel, Arnaud, Robert, Guillaume, Pagès, Gilles, Auberger, Patrick
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2017
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834281/
https://ncbi.nlm.nih.gov/pubmed/29541386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23650
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