Structural basis of ribosomal peptide macrocyclization in plants

Constrained, cyclic peptides encoded by plant genes represent a new generation of drug leads. Evolution has repeatedly recruited the Cys-protease asparaginyl endopeptidase (AEP) to perform their head-to-tail ligation. These macrocyclization reactions use the substrates amino terminus instead of wate...

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Veröffentlicht in:eLife
Hauptverfasser: Haywood, Joel, Schmidberger, Jason W, James, Amy M, Nonis, Samuel G, Sukhoverkov, Kirill V, Elias, Mikael, Bond, Charles S, Mylne, Joshua S
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2018
Schlagworte:
Structural Biology and Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834244/
https://ncbi.nlm.nih.gov/pubmed/29384475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32955
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