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Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products

[Image: see text] A thermodynamic approach to peptide macrocyclization inspired by the cyclization of non-ribosomal peptide aldehydes is presented. The method provides access to structurally diverse macrocycles by exploiting the reactivity of transient macrocyclic peptide imines toward inter- and in...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Malins, Lara R., deGruyter, Justine N., Robbins, Kevin J., Scola, Paul M., Eastgate, Martin D., Ghadiri, M. Reza, Baran, Phil S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391502/
https://ncbi.nlm.nih.gov/pubmed/28326777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b01624
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