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Structural basis for precursor protein-directed ribosomal peptide macrocyclization

Macrocyclization is a common feature of natural product biosynthetic pathways including the diverse family of ribosomal peptides. Microviridins are architecturally complex cyanobacterial ribosomal peptides whose members target proteases with potent reversible inhibition. The product structure is con...

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Udgivet i:Nat Chem Biol
Main Authors: Li, Kunhua, Condurso, Heather L., Li, Gengnan, Ding, Yousong, Bruner, Steven D.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117808/
https://ncbi.nlm.nih.gov/pubmed/27669417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2200
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