Autoregulation of von Willebrand factor function by a disulfide bond switch

Force-dependent binding of platelet glycoprotein Ib (GPIb) receptors to plasma von Willebrand factor (VWF) plays a key role in hemostasis and thrombosis. Previous studies have suggested that VWF activation requires force-induced exposure of the GPIb binding site in the A1 domain that is autoinhibite...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Butera, Diego, Passam, Freda, Ju, Lining, Cook, Kristina M., Woon, Heng, Aponte-Santamaría, Camilo, Gardiner, Elizabeth, Davis, Amanda K., Murphy, Deirdre A., Bronowska, Agnieszka, Luken, Brenda M., Baldauf, Carsten, Jackson, Shaun, Andrews, Robert, Gräter, Frauke, Hogg, Philip J.
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834005/
https://ncbi.nlm.nih.gov/pubmed/29507883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaq1477
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