Targeted reduction of the EGFR protein, but not inhibition of its kinase activity, induces mitophagy and death of cancer cells through activation of mTORC2 and Akt

The oncogenic epidermal growth factor receptor (EGFR) is commonly overexpressed in solid cancers. The tyrosine kinase activity of EGFR has been a major therapeutic target for cancer; however, the efficacy of EGFR tyrosine kinase inhibitors to treat cancers has been challenged by innate and acquired...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Katreddy, Rajasekhara Reddy, Bollu, Lakshmi Reddy, Su, Fei, Xian, Na, Srivastava, Shivangi, Thomas, Rintu, Dai, Yubing, Wu, Bing, Xu, Yunlu, Rea, Michael A., Briggs, James M., Zhang, Qingyuan, Lu, Xiongbin, Huang, Gangxiong, Weihua, Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833766/
https://ncbi.nlm.nih.gov/pubmed/29358623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-017-0021-7
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