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Kinase-Inactivated EGFR Is Required for the Survival of Wild-Type EGFR-Expressing Cancer Cells Treated with Tyrosine Kinase Inhibitors

Inhibiting the tyrosine kinase activity of epidermal growth factor receptor (EGFR) using small molecule tyrosine kinase inhibitors (TKIs) is often ineffective in treating cancers harboring wild-type EGFR (wt-EGFR). TKIs are known to cause dimerization of EGFR without altering its expression level. G...

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Dades bibliogràfiques
Publicat a:Int J Mol Sci
Autors principals: Thomas, Rintu, Srivastava, Shivangi, Katreddy, Rajasekhara Reddy, Sobieski, Jason, Weihua, Zhang
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566606/
https://ncbi.nlm.nih.gov/pubmed/31121829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20102515
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