Kinase-Inactivated EGFR Is Required for the Survival of Wild-Type EGFR-Expressing Cancer Cells Treated with Tyrosine Kinase Inhibitors

Inhibiting the tyrosine kinase activity of epidermal growth factor receptor (EGFR) using small molecule tyrosine kinase inhibitors (TKIs) is often ineffective in treating cancers harboring wild-type EGFR (wt-EGFR). TKIs are known to cause dimerization of EGFR without altering its expression level. G...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Thomas, Rintu, Srivastava, Shivangi, Katreddy, Rajasekhara Reddy, Sobieski, Jason, Weihua, Zhang
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566606/
https://ncbi.nlm.nih.gov/pubmed/31121829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20102515
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