Targeted reduction of the EGFR protein, but not inhibition of its kinase activity, induces mitophagy and death of cancer cells through activation of mTORC2 and Akt

The oncogenic epidermal growth factor receptor (EGFR) is commonly overexpressed in solid cancers. The tyrosine kinase activity of EGFR has been a major therapeutic target for cancer; however, the efficacy of EGFR tyrosine kinase inhibitors to treat cancers has been challenged by innate and acquired...

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Bibliografiset tiedot
Julkaisussa:Oncogenesis
Päätekijät: Katreddy, Rajasekhara Reddy, Bollu, Lakshmi Reddy, Su, Fei, Xian, Na, Srivastava, Shivangi, Thomas, Rintu, Dai, Yubing, Wu, Bing, Xu, Yunlu, Rea, Michael A., Briggs, James M., Zhang, Qingyuan, Lu, Xiongbin, Huang, Gangxiong, Weihua, Zhang
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833766/
https://ncbi.nlm.nih.gov/pubmed/29358623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-017-0021-7
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