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Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation

Epidermal growth factor receptor (EGFR) is an oncogenic receptor tyrosine kinase. Canonically, the tyrosine kinase activity of EGFR is regulated by its extracellular ligands. However, ligand-independent activation of EGFR exists in certain cancer cells, and the underlying mechanism remains to be def...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bollu, Lakshmi Reddy, Katreddy, Rajashekhara Reddy, Blessing, Alicia Marie, Pham, Nguyen, Zheng, Baohui, Wu, Xu, Weihua, Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741504/
https://ncbi.nlm.nih.gov/pubmed/26378037
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