Inhibition of DHHC20 mediated EGFR palmitoylation creates a dependence on EGFR signaling

Inappropriate activation of the receptor tyrosine kinase EGFR contributes to a variety of human malignancies. Here we show a mechanism to induce vulnerability to an existing first line treatment for EGFR driven cancers. We find that inhibiting the palmitoyltransferase DHHC20 creates a dependence on...

全面介紹

Na minha lista:
書目詳細資料
發表在:Mol Cell
Main Authors: Runkle, Kristin B., Kharbanda, Akriti, Stypulkowski, Ewa, Cao, Xing-Jun, Wang, Wei, Garcia, Benjamin A., Witze, Eric S.
格式: Artigo
語言:Inglês
出版: 2016
主題:
Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860254/
https://ncbi.nlm.nih.gov/pubmed/27153536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.04.003
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍