A carregar...
Inhibition of DHHC20 mediated EGFR palmitoylation creates a dependence on EGFR signaling
Inappropriate activation of the receptor tyrosine kinase EGFR contributes to a variety of human malignancies. Here we show a mechanism to induce vulnerability to an existing first line treatment for EGFR driven cancers. We find that inhibiting the palmitoyltransferase DHHC20 creates a dependence on...
Na minha lista:
| Publicado no: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4860254/ https://ncbi.nlm.nih.gov/pubmed/27153536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.04.003 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|