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Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis
Nonsmall cell lung cancer (NSCLC) is often characterized by mutually exclusive mutations in the epidermal growth factor receptor (EGFR) or the guanosine triphosphatase KRAS. We hypothesized that blocking EGFR palmitoylation, previously shown to inhibit EGFR activity, might alter downstream signaling...
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| Udgivet i: | Sci Signal |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7310254/ https://ncbi.nlm.nih.gov/pubmed/32127496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aax2364 |
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