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Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis
Nonsmall cell lung cancer (NSCLC) is often characterized by mutually exclusive mutations in the epidermal growth factor receptor (EGFR) or the guanosine triphosphatase KRAS. We hypothesized that blocking EGFR palmitoylation, previously shown to inhibit EGFR activity, might alter downstream signaling...
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| Publicado no: | Sci Signal |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7310254/ https://ncbi.nlm.nih.gov/pubmed/32127496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aax2364 |
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