INHIBITION OF MUC1-C SUPPRESSES MYC EXPRESSION AND ATTENUATES MALIGNANT GROWTH IN KRAS MUTANT LUNG ADENOCARCINOMAS

Dysregulation of MYC expression is a hallmark of cancer, but the development of agents that target MYC has remained challenging. The oncogenic MUC1-C transmembrane protein is, like MYC, aberrantly expressed in diverse human cancers. The present studies demonstrate that MUC1-C induces MYC expression...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Bouillez, Audrey, Rajabi, Hasan, Pitroda, Sean, Jin, Caining, Alam, Maroof, Kharbanda, Akriti, Tagde, Ashujit, Wong, Kwok-Kin, Kufe, Donald
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794417/
https://ncbi.nlm.nih.gov/pubmed/26833129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1804
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