MUC1-C drives MYC in multiple myeloma

Multiple myeloma (MM) cell lines and primary tumor cells are addicted to the MYC oncoprotein for survival. Little is known, however, about how MYC expression is upregulated in MM cells. The mucin 1 C-terminal subunit (MUC1-C) is an oncogenic transmembrane protein that is aberrantly expressed in MM c...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Tagde, Ashujit, Rajabi, Hasan, Bouillez, Audrey, Alam, Maroof, Gali, Reddy, Bailey, Shannon, Tai, Yu-Tzu, Hideshima, Teru, Anderson, Kenneth, Avigan, David, Kufe, Donald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882805/
https://ncbi.nlm.nih.gov/pubmed/26907633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-07-659151
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