MUC1-C induces DNA methyltransferase 1 and represses tumor suppressor genes in acute myeloid leukemia

Aberrant DNA methylation is a hallmark of acute myeloid leukemia (AML); however, the regulation of DNA methyltransferase 1 (DNMT1), which is responsible for maintenance of DNA methylation patterns, has largely remained elusive. MUC1-C is a transmembrane oncoprotein that is aberrantly expressed in AM...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Tagde, Ashujit, Rajabi, Hasan, Stroopinsky, Dina, Gali, Reddy, Alam, Maroof, Bouillez, Audrey, Kharbanda, Surender, Stone, Richard, Avigan, David, Kufe, Donald
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
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Priority Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129907/
https://ncbi.nlm.nih.gov/pubmed/27259275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9777
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