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Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation

Epidermal growth factor receptor (EGFR) is an oncogenic receptor tyrosine kinase. Canonically, the tyrosine kinase activity of EGFR is regulated by its extracellular ligands. However, ligand-independent activation of EGFR exists in certain cancer cells, and the underlying mechanism remains to be def...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Bollu, Lakshmi Reddy, Katreddy, Rajashekhara Reddy, Blessing, Alicia Marie, Pham, Nguyen, Zheng, Baohui, Wu, Xu, Weihua, Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741504/
https://ncbi.nlm.nih.gov/pubmed/26378037
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