PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations

Somatic activating mutations within the PIK3CA gene have been recently detected in sporadic lymphatic and venous malformations, and in vascular malformations (VM) associated to overgrowth syndromes, such as CLOVES and Klippel–Trenaunay syndrome. Although VM are often limited to specific tissue areas...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: di Blasio, Laura, Puliafito, Alberto, Gagliardi, Paolo Armando, Comunanza, Valentina, Somale, Desiana, Chiaverina, Giulia, Bussolino, Federico, Primo, Luca
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833448/
https://ncbi.nlm.nih.gov/pubmed/29352118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0064-x
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