Activation of RSK by phosphomimetic substitution in the activation loop is prevented by structural constraints

The activation of the majority of AGC kinases is regulated by two phosphorylation events on two conserved serine/threonine residues located on the activation loop and on the hydrophobic motif, respectively. In AGC kinase family, phosphomimetic substitutions with aspartate or glutamate, leading to co...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Somale, Desiana, Di Nardo, Giovanna, di Blasio, Laura, Puliafito, Alberto, Vara-Messler, Marianela, Chiaverina, Giulia, Palmiero, Miriam, Monica, Valentina, Gilardi, Gianfranco, Primo, Luca, Gagliardi, Paolo Armando
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969211/
https://ncbi.nlm.nih.gov/pubmed/31953410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56937-3
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