Activation of RSK by phosphomimetic substitution in the activation loop is prevented by structural constraints

The activation of the majority of AGC kinases is regulated by two phosphorylation events on two conserved serine/threonine residues located on the activation loop and on the hydrophobic motif, respectively. In AGC kinase family, phosphomimetic substitutions with aspartate or glutamate, leading to co...

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Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Somale, Desiana, Di Nardo, Giovanna, di Blasio, Laura, Puliafito, Alberto, Vara-Messler, Marianela, Chiaverina, Giulia, Palmiero, Miriam, Monica, Valentina, Gilardi, Gianfranco, Primo, Luca, Gagliardi, Paolo Armando
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969211/
https://ncbi.nlm.nih.gov/pubmed/31953410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56937-3
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