Activation of RSK by phosphomimetic substitution in the activation loop is prevented by structural constraints

The activation of the majority of AGC kinases is regulated by two phosphorylation events on two conserved serine/threonine residues located on the activation loop and on the hydrophobic motif, respectively. In AGC kinase family, phosphomimetic substitutions with aspartate or glutamate, leading to co...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Somale, Desiana, Di Nardo, Giovanna, di Blasio, Laura, Puliafito, Alberto, Vara-Messler, Marianela, Chiaverina, Giulia, Palmiero, Miriam, Monica, Valentina, Gilardi, Gianfranco, Primo, Luca, Gagliardi, Paolo Armando
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969211/
https://ncbi.nlm.nih.gov/pubmed/31953410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56937-3
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