PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations

Somatic activating mutations within the PIK3CA gene have been recently detected in sporadic lymphatic and venous malformations, and in vascular malformations (VM) associated to overgrowth syndromes, such as CLOVES and Klippel–Trenaunay syndrome. Although VM are often limited to specific tissue areas...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: di Blasio, Laura, Puliafito, Alberto, Gagliardi, Paolo Armando, Comunanza, Valentina, Somale, Desiana, Chiaverina, Giulia, Bussolino, Federico, Primo, Luca
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833448/
https://ncbi.nlm.nih.gov/pubmed/29352118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0064-x
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