PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations

Somatic activating mutations within the PIK3CA gene have been recently detected in sporadic lymphatic and venous malformations, and in vascular malformations (VM) associated to overgrowth syndromes, such as CLOVES and Klippel–Trenaunay syndrome. Although VM are often limited to specific tissue areas...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: di Blasio, Laura, Puliafito, Alberto, Gagliardi, Paolo Armando, Comunanza, Valentina, Somale, Desiana, Chiaverina, Giulia, Bussolino, Federico, Primo, Luca
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833448/
https://ncbi.nlm.nih.gov/pubmed/29352118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0064-x
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