PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations

Somatic activating mutations within the PIK3CA gene have been recently detected in sporadic lymphatic and venous malformations, and in vascular malformations (VM) associated to overgrowth syndromes, such as CLOVES and Klippel–Trenaunay syndrome. Although VM are often limited to specific tissue areas...

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Detaylı Bibliyografya
Yayımlandı:Cell Death Dis
Asıl Yazarlar: di Blasio, Laura, Puliafito, Alberto, Gagliardi, Paolo Armando, Comunanza, Valentina, Somale, Desiana, Chiaverina, Giulia, Bussolino, Federico, Primo, Luca
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833448/
https://ncbi.nlm.nih.gov/pubmed/29352118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0064-x
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