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Cooperative metal ion binding and general base activation in hammerhead ribozyme catalysis

The hammerhead ribozyme is a well-studied nucleolytic ribozyme that catalyzes the self-cleavage of the RNA phosphodiester backbone. Despite experimental and theoretical efforts, there remain key questions about details of the mechanism with regard to the activation of the nucleophile by the putative...

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Bibliografiset tiedot
Julkaisussa:Biochemistry
Päätekijät: Chen, Haoyuan, Giese, Timothy J., Golden, Barbara L., York, Darrin M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832362/
https://ncbi.nlm.nih.gov/pubmed/28530384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01192
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