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Cooperative metal ion binding and general base activation in hammerhead ribozyme catalysis

The hammerhead ribozyme is a well-studied nucleolytic ribozyme that catalyzes the self-cleavage of the RNA phosphodiester backbone. Despite experimental and theoretical efforts, there remain key questions about details of the mechanism with regard to the activation of the nucleophile by the putative...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Biochemistry
Asıl Yazarlar: Chen, Haoyuan, Giese, Timothy J., Golden, Barbara L., York, Darrin M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832362/
https://ncbi.nlm.nih.gov/pubmed/28530384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01192
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