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Cooperative metal ion binding and general base activation in hammerhead ribozyme catalysis

The hammerhead ribozyme is a well-studied nucleolytic ribozyme that catalyzes the self-cleavage of the RNA phosphodiester backbone. Despite experimental and theoretical efforts, there remain key questions about details of the mechanism with regard to the activation of the nucleophile by the putative...

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Foilsithe in:Biochemistry
Main Authors: Chen, Haoyuan, Giese, Timothy J., Golden, Barbara L., York, Darrin M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832362/
https://ncbi.nlm.nih.gov/pubmed/28530384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01192
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