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Cooperative metal ion binding and general base activation in hammerhead ribozyme catalysis

The hammerhead ribozyme is a well-studied nucleolytic ribozyme that catalyzes the self-cleavage of the RNA phosphodiester backbone. Despite experimental and theoretical efforts, there remain key questions about details of the mechanism with regard to the activation of the nucleophile by the putative...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Chen, Haoyuan, Giese, Timothy J., Golden, Barbara L., York, Darrin M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832362/
https://ncbi.nlm.nih.gov/pubmed/28530384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01192
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