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Cooperative metal ion binding and general base activation in hammerhead ribozyme catalysis
The hammerhead ribozyme is a well-studied nucleolytic ribozyme that catalyzes the self-cleavage of the RNA phosphodiester backbone. Despite experimental and theoretical efforts, there remain key questions about details of the mechanism with regard to the activation of the nucleophile by the putative...
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| Publicat a: | Biochemistry |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5832362/ https://ncbi.nlm.nih.gov/pubmed/28530384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01192 |
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