Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity

HIV-1 broadly neutralizing antibodies (bNAbs) are being explored as passively administered therapeutic and preventative agents. However, the extensively diversified HIV-1 envelope glycoproteins (Env) rapidly acquire mutations to evade individual bNAbs in monotherapy regimens. The use of a “single” a...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Steinhardt, James J., Guenaga, Javier, Turner, Hannah L., McKee, Krisha, Louder, Mark K., O’Dell, Sijy, Chiang, Chi-I, Lei, Lin, Galkin, Andrey, Andrianov, Alexander K., A. Doria-Rose, Nicole, Bailer, Robert T., Ward, Andrew B., Mascola, John R., Li, Yuxing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830440/
https://ncbi.nlm.nih.gov/pubmed/29491415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03335-4
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